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Myasthenia gravis (gMG) is a critical autoimmune disease, which has a
serious impact on the life and survival of patients. Ocular Myasthenia
Gravis (oMG) is often the initial manifestation of MG and has the
potential to progress to gMG. However, to date no distinct mechanism
has been found to clarify the pathogenesis of conversion from oMG
to gMG. Recent studies have shown that the development and clinical
progression of MG is closely associated with the abnormal function
of follicular helper T (Tfh) cells. Thus, this article reviews the recently
achieved research progress on the involvement of Tfh cells in MG
immunopathogenesis and focuses on the role of Tfh cells and relatedfactors (IL-21, CXCL13, CXCR5, bcl-6 etc.) in germinal center formation
and antibody production in MG immune response.