Introductıon: Long-reported dual comorbidity between migraine and
sleep disorders suggests that some gene variations may play a role in
this relationship. Our previous study found an association between poor
sleep quality and the G allele of the hypocretin receptor 1 (HCRTR1)
rs2271933 gene in patients with chronic migraine (CM). This study aimed
to examine the relationship of this gene with some sleep parameters.
Methods: The present study was designed cross-sectional in the Mersin
University Neurology Clinic between January 2000 and February 2018.
Patients aged 18–75 years with CM according to the International
Classification of Headache Disorders-3 (ICHD-3) criteria were included.
The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep
quality of the patients. Patients were divided into two groups according
to PSQI scores <6 or ≥6. Genotyping was performed for the HCRTR1
rs2271933 gene.
Results: Among the 100 patients with CM, only the data of those (n=67)
with poor sleep quality were included in this study. The mean age of
patients was 40.9±11.8%, and the female rate was 89.6%. We detected
that increasing the time to fall asleep (p=0.369) and the rate of poor sleep
quality (p=0.461) and also shortening sleep duration (p=0.016) with the
increase of G allele carrier of HCRTR1 rs2271933 gene.
Conclusıon: As the G allele carrier of the HCRTR1 rs2271933 gene
increased, a shorter sleep duration was observed. This finding may
contribute to studies on the physiological roles of orexins.
Keywords: Chronic migraine, HCRTR1 rs2271933, poor sleep quality,
sleep duration, sleep latency