E-ISSN 1309-4866
Araştırma Makalesi
Changes in Cerebral Blood Flow in Patients with Familial Mediterranean Fever
1 Department of Internal Medicine, Division of Rheumatology, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey  
2 Department of Neurology, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey  
3 Department of Chest Diseases, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey  
4 Department of Internal Medicine, Kahramanmaraş Sütçü İmam University School of Medicine, Kahramanmaraş, Turkey  
Arch Neuropsychiatry ; : -
DOI: 10.5152/npa.2016.12396
625 kez okundu, 0 kez indirildi

Anahtar Kelimeler: FMF, inflammation, atherosclerosis, TCD, stroke
Özet

Introduction: It is known that there is a relationship between systemic inflammation and atherosclerosis. Atherosclerosis is one of the best known causes of cerebrovascular diseases. The aim of this study was to assess the cerebral blood flow velocity using transcranial Doppler (TCD) ultrasonography in patients with familial Mediterranean fever (FMF).

 

Methods: A total of 30 patients aged 20 to 50-years-old with FMF were enrolled in the FMF group consecutively. Control group (non-FMF group) consisted of 30 age and sex-matched, randomly selected patients without FMF who had other diagnosis such as fibromyalgia and did not have risk factors for atherosclerosis. Bilateral middle cerebral artery (MCA) peak-systolic, end-diastolic, and mean blood flow velocities, Gosling’s pulsatility index values, and Pourcelot’s resistance index values were recorded with TCD by a neurosonologist blinded to FMF and control groups.

 

Results: There were 30 participants in the FMF group in remission (male/female: 4/26, mean age: 34.7±5.9) and 30 participants in control group (male/female: 4/26, mean age: 32.3±4.7). C-reactive protein (CRP) levels and blood flow velocities of bilateral MCA were significantly higher in FMF group than the control group.

 

Conclusion: This study suggests that the persistent clinical and subclinical inflammation in patients with FMF causes increased cerebral blood flow velocities. Our findings provide an insight to this association of FMF and cerebrovascular diseases. 

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