E-ISSN 1309-4866
Research Article
Guillain-Barre Syndrome and its Variants: Clinical Course and Prognostic Factors
1 Department of Neurology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey  
Arch Neuropsychiatry ; : -
DOI: 10.5152/npa.2017.18091
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Key Words: Guillain-Barre syndrome, intravenous immunoglobulin, prognosis

Introduction: We aimed to analyze the frequency, clinical characteristics, medical treatment options and final functional status of Guillain-Barre syndrome (GBS) and its variants in a population from a tertiary hospital setting.


Methods: All medical records of patients with acute inflammatory polyneuropathy between the years of 1998-2013 were retrospectively screened. Demographic, clinical and laboratory information, treatment options and the rate of recovery of the patients were gathered.


Results: A total of 183 patients met the study criteria. Subtypes were typical demyelinating form (n=102, 79.1%), acute motor sensory axonal (n=11, 8.5%), acute motor axonal (n=10, 7.8%), Miller-Fisher syndrome (n=5, 3.9%), pure sensory subtype (n=1, 0.8%).The data of treatment option were available for 70 patients. Most of the patients received intravenous immunoglobulin (IVIg) treatment or the combination of IVIG and methylprednisolone. One patient died, there was no improvement in eight patients and rest showed improvement.



Conclusions: We did not observe major change of recovery between different treatment options, however, most of the patients using methylprednisolone required IVIg because of inadequate response.

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Latest Update: 29.12.2017