E-ISSN 1309-4866
Research Article
Psychosocial and Medical Determinants of Health-related Quality of Life in Patients with Relapsing-Remitting Multiple Sclerosis
1 Department of Psychology, Semnan University, Semnan, Iran  
2 Department of Psychology, Researches & Sciences University, Semnan, Iran  
Arch Neuropsychiatry ; : -
DOI: 10.5152/npa.2017.16983
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Key Words: Quality of life, depression, psychosocial, multiple sclerosis

Introduction: Relapsing-remitting multiple sclerosis as a debilitating neurological disease accompanied with adverse consequences for quality of life. The purpose of this study was to investigate the role of psychological, disease-related, socioeconomic and demographic determinants of health-related quality of life in patients with relapsing-remitting multiple sclerosis.


Methods: In this cross-sectional descriptive study, 193 patients with relapsing-remitting multiple sclerosis selected by compliance sampling method among the patients whom attended the Iranian Multiple Sclerosis Association in Tehran from Mar 2014 to July 2014 and they completed the Multiple Sclerosis Quality of Life Questionnaire, the Depression Anxiety and Stress Scales and the Socio-demographical Questionnaire. Then, a hierarchical multiple regression analysis with the stepwise method used for data analysis by the PASW-18.


Results: According to the findings, in model 1, low SES had a negative coefficient (beta=-0.30, p<.01) and treatment history had a positive coefficient (beta=0.22, p<0.01). In model 2 while all variables of model 1 controlled, depression had a negative coefficient (beta=-0.26, p<.05), while disorder severity of multiple sclerosis had positive coefficients in lower level (beta=.35, p<.001), moderate level (beta=.23, p<.01) and severe level (beta=.22, p<.01). Other studied variables in model 1 and stress and anxiety in model 2 weren’t predicted the quality of life (p>0.05).



Conclusion: Unfavorable SES, lack of effective treatment history, higher depression, and signs and symptom severity of multiple sclerosis significantly predict decreased health-related quality of Life in patients with relapsing-remitting multiple sclerosis. Thus, it is consequential to emphasize the value of tailored intervention for attending to these factors in the treatment and rehabilitation agendas for improvement of health-related quality of Life in relapsing-remitting multiple sclerosis.

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Latest Update: 29.12.2017