E-ISSN 1309-4866
Research Article
Electrophysiological Subtypes and Prognostic Factors of Childhood Guillain Barre Syndrome
1 Department of Pediatric Neurology, Hacettepe University School of Medicine, Ankara, Turkey  
2 Department of Pediatric Neurology, Mersin University School of Medicine, Mersin, Turkey  
3 Department of Biostatistics, Mersin University School of Medicine, Mersin, Turkey  
4 Department of Pediatric Neurology, Dokuz Eylül University School of Medicine, İzmir, Turkey  
5 Turkish Childhood Guillan-Barre Syndrome Study Group  
Arch Neuropsychiatry ; : -
DOI: 10.5152/npa.2017.16996
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Key Words: Guillain-Barre Syndrome, childhood, electroneuromyography
Abstract

Introduction: We assessed the clinical, epidemiologic, electrophysiologic and prognostic characteristics of childhood GBS admitted to 13 pediatric neurology centers in Turkey.

 

Methods: Using a standard data recording form age, sex, duration of symptoms, distribution of weakness at onset, cranial nerve involvement, CSF findings, electrophysiological findings, duration of hospitalization, requirement of ventilation, treatment and clinical evaluation scale at onset, discharge and 1-3-6-12 months after discharge were recorded.

 

Results: Among the 236 children with a median age of 6.8 years there was a male to female ratio of 1.3. Based on the electrophysiological features; 84 patients were classified as acute inflammatory demyelinating polyrediculoneuropathy (AIDP), 61 as acute motor axonal neuropathy (AMAN), 21 as acute motor-sensory axonal neuropathy (AMSAN). The incidence of cranial nerve involvement was 16% and was related to lower clinical scores at discharge and 6 months after discharge. Clinical scale scores between axonal and demyelinating subgroups did not show statistically significant difference except for admission (p<0.05).

 

Conclusion: Electrophysiological subtypes are not important in prognosis in our series. However, duration of weakness, duration of hospitalization and ventilation requirement can affect prognosis negatively.

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