E-ISSN 1309-4866
Research Article
The Phenotypic Variants of Patients with Progressive Supranuclear Palsy
1 Department of Neurology, Erciyes University School of Medicine, Kayseri, Turkey  
Arch Neuropsychiatry ; : -
DOI: 10.5152/npa.2017.22771
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Key Words: Progressive supranuclear palsy, phenotype, variant
Abstract

Introduction: Progressive supranuclear palsy (PSP) is a commonly seen disease among Parkinson plus syndromes and an early and accurate diagnosis is usually not possible. Nowadays, PSP is reported to have eight different subtypes. This study aims to determine phenotypic subtypes of PSP patients and reveal accompanying characteristics. 

 

Methods: Eighteen PSP patients diagnosed with PSP according to NINDS-SPSP criteria were included in the study. Initial symptoms of the patients, their initial diagnosis, course of the disease in time, cranial images, and predominant clinical characteristics were assessed according to subtypes of PSP. Results: Eighteen PSP patients were included in the study. The half of the patients were male. The mean age of the patients was found to be 65.83.   All patients were assessed as ‘Probable PSP’ according to NINDS-SPSP criteria. An evaluation of PSP patients based on subtypes showed that five different subtypes were predominant characteristics. Richardson's syndrome (PSP-RS) was found to be the most common subtype. 

 

 

Results: Eighteen PSP patients were included in the study. The half of the patients were male. The mean age of the patients was found to be 65.83.   All patients were assessed as ‘Probable PSP’ according to NINDS-SPSP criteria. An evaluation of PSP patients based on subtypes showed that five different subtypes were predominant characteristics. Richardson's syndrome (PSP-RS) was found to be the most common subtype.  

 

Conclusion: It may be useful to classify PSP into its phenotypes for informing clinicians about diverse clinical presentations of the disease, and thus improvements may be made in the diagnostic sensitivity of the disease.

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