E-ISSN 1309-4866
Invited Review
Motor Unit Number Estimation Techniques
1 Hamidiye Şişli Etfal Eğitim ve Araştırma Hastanesi, Nöroloji Kliniği, İstanbul, Türkiye  
2 İstanbul Üniversitesi İstanbul Tıp Fakültesi, Nöroloji Anabilim Dalı, Klinik Nörofizyoloji Bilim Dalı, İstanbul, Türkiye  
Arch Neuropsychiatry ; : -
DOI: 10.5152/npa.2016.12491
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Key Words: Compound muscle action potential, motor unit, motor unit number estimation
Abstract

The motor unit consists of an anterior horn cell, its axon and the muscle fibers that it innervates. Motor unit number, is an important measure in the evaluation of the diseases associated with motor neuronal and/or axonal degeneration. Although we have the opportunity of gathering information, by using other neurophysiological methods, about the function of the motor units, the results gained by most of these methods are contaminated by the effects of collateral reinnervation which has the potential of masking the amount of motor neuronal loss. Motor unit number estimation (MUNE) methods aim to give quantitative information on the number and size of the motor units. The first electrophysiological MUNE technique was described in 1971 by McComas and coworkers. Since that time, different MUNE methods have been put forward, each having advantages and limitations of its own. Howewer, all MUNE techniques are based on the same simple principle. Techniques differ in determining the size of the surface recorded motor units (S-MUPs) representing the whole motor unit population. Each technique includes a final simple calculation. MUNE value is obtained by dividing the size of the maximal compound muscle action potential to the size of S-MUP.

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