E-ISSN 1309-4866
Research Article
Do Low Serum UCH-L1 and TDP-43 Levels Indicate Disturbed Ubiquitin-Proteosome System in Autism Spectrum Disorder?
1 Department of Nutrition and Dietetics, Batman University School of Health, Batman, Turkey  
2 Department of Chemistry, Batman University Institute of Science, Batman, Turkey  
3 Department of Child and Adolescent Psychiatry, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey  
4 Department of Child and Adolescent Psychiatry, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey  
5 Department of Psychiatry, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey  
6 Department of Biochemistry, Bezmialem Vakif University School of Medicine, İstanbul, Turkey  
7 Department of Pediatrics, Medipol University School of Medicine, İstanbul, Turkey  
Arch Neuropsychiatry 2017; 54: 267-271
DOI: 10.5152/npa.2017.14873
This article was viewed 33 times, downloaded 11 times

Key Words: Autism, UCH-L1, TDP-43, ubiquitination
Abstract

Introduction: The mechanism of ubiquitination-related abnormalities causing neural development problems is still unclear. We examined the association between autism and serum transactive response DNA-binding protein-43 (TDP-43) and ubiquitin c-terminal hydrolase-L1 (UCH-L1) levels, both of which are members of the ubiquitin-proteosome system.

 

Methods: We measured serum levels of TDP-43 and UCH-L1 in 24 children with autism and 24 healthy children. Childhood Autism Rating Scale (CARS) was used to assess symptom severity at admission.

 

Results: The mean serum TDP-43 and UCH-L1 levels in children with autism spectrum disorder (ASD) were found to decrease compared to healthy controls (p<0.001, 506.21±780.97 ng/L and 1245.80±996.76 ng/L, respectively; 3.08±5.44 ng/mL and 8.64±6.67 ng/mL, respectively). A positive correlation between serum TDP-43 levels and UCH-L1 levels was found in the ASD group (r=0.947, n=24, p<0.001). The CARS score of children with ASD was 48.91 points (standard deviation [SD]: 5.82).

 

Conclusion: Low serum levels of UCH-L1 and TDP-43 may reflect disturbed ubiquitination in autism.

 

Cite this article as: Çetin İ, Tezdiğ İ, Tarakçioğlu MC, Kadak MT, Demirel ÖF, Özer ÖF, Erdoğan F, Doğangün B. Do Low Serum UCH-L1 and TDP-43 Levels Indicate Disturbed Ubiquitin-Proteosome System in Autism Spectrum Disorder? Arch Neuropsychiatry 2017; 54:267-271.

Key Words
Authors
All
Author's Corner
Announcements
Survey
AVES | Copyright © 2017 Turkish Neuropsychiatric Society | Latest Update: 03.10.2017