E-ISSN 1309-4866
Research Article
Comparison of Brain Atrophy, Cognition and Optical Coherence Tomography Results Between Multiple Sclerosis Patients and Healthy Controls
1 Ankara Atatürk Eğitim ve Araştırma Hastanesi, Nöroloji Kliniği, Ankara, Türkiye  
2 Uludağ Üniversitesi Tıp Fakültesi, Nöroloji Anabilim Dalı, Bursa, Türkiye  
3 Çorum İskilip Devlet Hastanesi, Radyoloji Bölümü, Çorum, Türkiye  
4 İstanbul Üniversitesi İstanbul Tıp Fakültesi, Nöroloji Anabilim Dalı, İstanbul, Türkiye  
5 Keçiören Eğitim ve Araştırma Hastanesi, Dahiliye Kliniği, Ankara, Türkiye  
Arch Neuropsychiatry ; : -
DOI: 10.5152/npa.2017.12534
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Key Words: Multiple sclerosis, brain atrophy, cognition

Introduction:  Cognitive  impairment is  also an important   cause  of  disability in MS  in addition to motor, sensory,visual and  cerebellar  affections . The aim of this study is to show the relation between the cognitive disability in MS with  brain atrophy and retinal nerve fiber layer (RNFL).


Methods: Forty-three multiple sclerosis (MS) patients and 15 healthy individuals as controls were included in the study. MS patients were divided into three groups as relapsing-remitting MS (RRMS), relapsing-remitting with optic neuritis (RRMS+ON) and secondary-progressive MS (SPMS). An experienced psychologist performed modified Wechsler Memory Scale Revised form (WMS-R), Lines Orientation test, Stroop Color Word Interference test (STROOP), Standard Raven Progressive Matrices (SRPM), Benton Facial Recognition Test, verbal fluency test  and  Paced Auditory Serial Addition tests in all cases. Optic coherence tomographies(OCT) were done. Cranial subcortical volumes of all  subjects were measured using  3-dimensonal T1A imagines  obtained  by the cranial subcortical 1.5 tesla MR device (full automatical Freesurfer program ). Brain parenchymal fractions were calculated using the obtained volume measurements proportioning to the total intracranial volume.


Results: Fifty eight subjects (65,5% female, 34,5% male) were enrolled in the study. There was a  significant difference between  groups  in terms of parenchymal thickness, volumes of third ventricle  and  white matter. There was significant correlation between the volumes of the deep gray matter, mesial temporal structures and lateral ventricular volumes and the test results of the WMS-R. OCT scores of all MS patients, whether or not they experienced optic neuritis, had increased, being worse especially in the SPMS group. Correlations between RNFL and the brain parenchymal fractions of the patients were statistically significant.


Conclusion: Manual methods instead of automatic segmentation method are being more commonly used in the studies with brain atrophy and MS in our country. A significant correlation between OCT scores and brain atrophy is shown with our present study and this is followed as a reflection of decrease in cognitive tests that gives a valuable and reliable knowledge to the literature.  

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Latest Update: 29.12.2017