E-ISSN 1309-4866
Research Article
Comparing Coloured and Black-White Visual Evoked Potentials Vep in Multiple Sclerosis Patients
1 Department of Neurology, Bakırkoy Training and Research Hospital for Psychiatry, Neurology and Neurosurgery, İstanbul, Turkey  
2 Department of Ophthalmology, Bakırkoy Sadi Konuk Training and Research Hospital, İstanbul, Turkey  
Arch Neuropsychiatry ; : -
DOI: 10.5152/npa.2017.22787
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Key Words: Multiple sclerosis, optic neuritis, colored visual evoked potentials, optical coherans tomography

Introduction: We compared white-black (wb), white-red (wr) and black-red (br) checker board stimulatedvisual evoked potentials (VEPs) in Multiple Sclerosis (MS) patients and aimed to evaluate if red coloured VEP is more sensitive than ‘wb’ VEP for the diagnosis of optic neuritis (ON).


Methods: Twenty-nine MS patients (21 females (72.4%)) and 35 healthy control subjects (24 females (68.6%)) were included in the study. Neurological and ophthalmological examinations were conducted for all subjects and VEP and Optical Coherence Tomography (OCT) investigations were performed.


Results: A significant difference was found between MS patients and the control group for ‘wb’, ‘wr’, ‘br’ stimulation VEP P100 latencies, Retinal Nerve Fibre Length (RNFL) and Ganglion Cell Complex (GCC) thicknesses, but there was no difference for ‘wb’, ‘wr’ and ‘rb’ stimulated VEP amplitude values. There was no significant pathological difference between eyes with an ON history in MS, eyes without an ON history in MS and control subjects after ‘wb’, ‘wr’ and ‘br’ stimulation.


Conclusions: The ‘wb’ checker board stimulated VEP is an ample test to use routinely and further studies are necessary regarding the utility of ‘rb’ stimulated VEP in detecting subclinical ON.


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