E-ISSN 1309-4866
Case Report.
Two New Cases and the Review Of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) Syndrome with Long-Term Follow-Up
1 Department of Neurology, İnonu University School of medicine, Malatya, Turkey  
2 Department of Radiology, İnonu University School of medicine, Malatya, Turkey  
Arch Neuropsychiatry ; : -
DOI: 10.5152/npa.2017.22732
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Key Words: Clippers Syndrome, brainstem, immunosuppressive therapy, corticosteroids
Abstract

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disorder of the central nervous system. The pathophysiology of CLIPPERS is unknown. The disease has characteristic radiological lesions located in the pons, bulbus and cerebellum. Here we report two new cases and the review of CLIPPERS syndrome. A 35-year-old woman presented with a 2-month history of progressive double vision, vertigo, gait ataxia, nausea, and vomiting. The second case was a 40-year-old Iraqi man who presented with a 3-month history of vertigo, headache, and gait ataxia. Diagnoses of CLIPPERS were established based on findings of punctate, nodular enhancing lesions in the pons and bulbus in the first case and in the cerebellum in the second.  Our patients responded well to steroid therapy and remained relapse-free for 2 years. CLIPPERS is a rare autoimmune disorder with characteristic radiological findings. Long-term immunosuppressive therapy is necessary for treatment.

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